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Although intravenous glutathione delivers a much higher therapeutic dose that enhances its efficacy, it also provides a narrower margin of safety due to the possibility of overdose toxicity

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The pattern applies to the methylcobalamin formulation as well, though exact numbers may vary with the ODT delivery method

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Model fitting, refinement, and validation For the CBS FL basal state structures, initially, three CBS 516525 structures (PDB: 4COO) were fitted using Molrep 55 and the missing loop 513527 was manually built in Coot 56