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Blood Cancer J 11:24 Moreau P, Parmar G, Prince M, Ocio E, Karanes C, Madan S et al 2021 A multi-center, Phase 1b study to assess the safety, pharmacokinetics and efficacy of subcutaneous isatuximab plus pomalidomide and dexamethasone, in patients with relapsed/refractory multiple myeloma

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In this way, the LOD and LOQ of the conversion SIDA method were calculated from [ 15 N 13 ]-CNCbl instead of CNCbl using the reverse LC-MS/MS response curve

doi:10.1007/BF00275941 134

While efficacy endpoints for weight loss in those trials were modest, the compound exhibited a favorable safety profile, supporting its later GRAS designation for food use