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However, the timing of taking creatine won't impact training or performance

J Am Diet Assoc 98:10011008 Palheta MS, Graa JR, Santos AA et al (2014) The participation of the nitrergic pathway in increased rate of transitory relaxation of lower esophageal sphincter induced by rectal distension in dogs

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Some people who take high doses may experience some mild symptoms such as headache and nausea