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Nutrients 15, 5112

FIGURE 7 The strong role of severe oxidative stress, reduced antioxidant defenses like GSH with increased lipid peroxidation and malondialdehyde generation (213), lipid, protein and DNA oxidation with increased apoptosis and necrosis in atherosclerosis as a major cause of cardiovascular diseases and stroke, supports the use of complementary and alternative medicines, dietary supplements, and antioxidants with hardly any adverse effect, able to restore homeostasis reversing oxidative stress (214)

Eur J Pharmacol 685:5969 Harhai M, Harsing LG (2022) An overview of glycine transporter subtype 1 inhibitors under preclinical and clinical evaluation for the treatment of alcohol abuse

Neuroinflammation plays a potential role in the medulla oblongata after moderate traumatic brain injury in mice as revealed by nontargeted metabonomics analysis

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This polymorphism is responsible for a rise in SOD enzymatic activity used for detoxifying superoxide anion radicals, thus the resultant phenotypes produce a greater number of toxic intermediates as well as hydrogen peroxide