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This dual function allows for real-time monitoring of treatment response, further optimizing combination therapy approaches [203]

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These oligonucleotides typically contain at least one region of modified nucleotides that confers one or more beneficial properties (such as, e.g., increased nuclease resistance, increased uptake into cells, increased binding affinity for the RNA target) and a region that is a substrate for RNase H cleavage

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At the same time, the drastic reduction of serum testosterone levels induced by ADT produces multiple side effects such as bone fracture, cardiovascular disease, sexual dysfunction anemia