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It contains zinc-finger domains that bind to DNA, as well as a ligand-binding site that ensures specific activation by calcitriol ( Calcitriol also exerts rapid, non-genomic effects through the 1,25D-MARRS receptor (PDIA3), which is highly expressed in neurons, astrocytes, and endothelial cells ( Taken together, the widespread expression of VDRs and vitamin Dmetabolizing enzymes throughout the aging brain supports the plausibility of vitamin D as a neuromodulator in later life

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2007 Feb;21(1):259-64