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Description

Mitochondrial dysfunction is increasingly recognized as a contributor to neuropathy, particularly in diabetic and chemotherapy-induced forms where mitochondrial damage in dorsal root ganglion neurons precedes and contributes to axonal degeneration

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Cladribine is an antimetabolite that causes cell arrest in G1 in B-cell lymphoma cells by modulating the activity of apoptotic proteins, notably c-Flip L, Bax, and Death receptor 4 (DR4) and Caspase 8

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