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Although there is no evidence that supplements are helpful in the treatment of psychosis in general, based on the published studies, we believe that if we can detect MTHFR polymorphism in individuals with various psychiatric diseases, we might be able to differentiate those MTHFR-related psychiatric patients from non MTHFR deficient patients and develop specific clinical treatment strategies, such as folate or methylfolate supplement to reverse the symptoms

However, in one case, psychotic symptoms and seizures recurred despite continuous cyanocobalamin replacement therapy after the discontinuation of antipsychotic and antiseizure medications [90]

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