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Research has shown that ER stress-induced trypsin-like activity promotes the release of the inflammatory mediator C-X-C chemokine ligand 8 (CXCL8), thereby exacerbating the inflammatory process [89]

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5.2.4 Polyphenol oxidases (PPOs) PPOs are omnipresent Cu-containing enzymes which utilize molecular Oxygen for catalytic hydroxylation and dehydrogenation of o- diphenolic compounds like catechol and caffeic acid to their respective quinones, which leads to the alkylation of nucleophilic groups and self-polymerization to produce dark-coloured melanin polymers [185]

10.1016/j.phymed.2020.153218 328 SahaS.PanigrahiD