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Oocyte-specific deletion of furin leads to female infertility by causing early secondary follicle arrest in mice

118 YaoS.XuM.-D.WangY.ZhaoS.-T.WangJ.ChenG.-F.et al

In 2025% of cases, MTC occurs as part of multiple endocrine neoplasia syndromes type 2A or 2B (MEN2A/MEN2B), while the remainder are sporadic (69, 70)

Furthermore, inducing ferroptosis by inhibiting the cellular antioxidant system presents a potential therapeutic strategy for OS, as various anticancer agents exert their effects by targeting antioxidant system-related proteins such as GPX4 ( 3 Ferroptosis in bone microenvironment The bone microenvironment encompasses the local setting where bone tissue resides, comprising key cellular components such as osteoblasts, osteoclasts, and osteocytes within the tissue, along with adipocytes, vascular networks, immune cells, and an abundance of bone marrow and extracellular matrix (81)

doi: 10.1073/pnas.1215761109 23 KangAYeGAfkhamiSAleithanFSinghKDvorkin-GhevaAet al

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