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Vitamin C is a key antioxidant for immune function and tissue repair

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Excessive ROS not only causes DNA damage and genetic instability but also affects immune metabolism pathways, weakening the immune systems normal function, thus promoting cancer development and progression as well as cellular aging and tissue function decline 96

Specifically, the function of the gut microbiota impacts host iron absorption, while iron homeostasis in the host also influences the diversity, classification, function, and dominant bacterial community of the microbiota [65]

Exosomeencapsulated miR26a attenuates aldosteroneinduced tubulointerstitial fibrosis by inhibiting the CTGF/SMAD3 signaling pathway

TNF- activates multiple signaling pathways through binding to its receptors (TNFR1 and TNFR2), inducing the release of inflammatory mediators, cell proliferation, apoptosis, and immune cell recruitment, ultimately leading to chronic intestinal inflammation