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Ferroptotic AECs release bioactive molecules, including DAMPs, oxPLs, and lipid aldehydes (e.g.,4-HNE, MDA), promote monocyte infiltration by triggering the release of chemokines (like CCL2) and cytokines

This balance effectively acts as a metabolic control switch, fine-tuning cellular susceptibility to ferroptosis and representing a potential target for cancer therapies that target lipid metabolism vulnerabilities (Li et al., 2024)

One of the mechanisms by which FGF-2 enhances the biomechanical strength of tendon bone healing is through increased production of mesenchymal progenitor cells, and the other is by promoting the expression of SCX and Tnmd (Zhou et al., 2021) established two models, a chicken model of flexor tendon injury and a rat model of Achilles tendon injury, both with bFGF/VEGFA loaded nanoparticle-coated sutures for circular repair at the stump of the injured tendon

54 NietzelT.MostertzJ.RubertiC.NeG.FuchsP.WagnerS.et al (2020)

Tesamorelin has some of the strongest evidence for specifically reducing visceral abdominal fat

Thus, the widely assumed detrimental effect of GSH depletion in MASLD remains largely unproven and lacks direct causal evidence