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Ellagic acid prevents cisplatin-induced oxidative stress in liver and heart tissue of rats

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However, excessive accumulation of GSH precursors can overwhelm this reducing capacity, leading to reductive stress and aberrant mitochondrial H 2 O 2 production, a mechanism that is particularly pronounced in cancer cells characterized by elevated cysteine metabolism but limited antioxidant enzyme capacity 209

Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism

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