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Their impaired regulatory function contributes to epithelial barrier dysfunction, a key feature of UC pathology (81)

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Abbreviations AFP: Alpha-fetoprotein ATM: Ataxia telangiectasia mutated ATRA: All-trans retinoic acid BCR: Biochemical recurrence b-FGF: b-fibroblast growth factor C/EBP: CCAAT/enhancer-binding protein cdc25A: Cell division cycle 25A CMM: Cutaneous malignant melanoma ECM: Extracellular matrix ECs: Endothelial cells EHMT1: Euchromatin histone methyltransferase 1 ELFEMFs: Extremely low-frequency electromagnetic fields ER: Estrogen receptor FADD: Fas-associated death domain GIF: Growth inhibitory factor HIF-1: Hypoxia-inducible factor-1 IL: Interleukin KO: Knockout LOH: Loss of heterozygosity MCM-2: Minichromosome maintenance protein 2 MMP: Matrix metalloproteinase MTs: Metallothioneins NCBI: National Center of Biotechnology Information NF-B: Nuclear factor-B NPs: Nanoparticles PDGF: Platelet-derived growth factor PI3K: Phosphatidylinositol 3-kinase pRNA: Packaging RNA rPOA: Reducible poly(oligo-d-arginine) shMT: Short hairpin RNAs against MTs siRNA: Short interfering RNA SMCs: Smooth muscle cells SNP: Single nucleotide polymorphism TGCTs: Testicular germ cell tumors TGF1: Transforming growth factor 1 TNM: Tumor node metastasis tPSA: Total prostate-specific antigen VEGF: Vascular endothelial growth factor References Coyle P, Philcox JC, Carey LC, Rofe AM

By altering muscle protein degradation rates, it could accelerate the age-related loss of muscle proteins

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Hydroxyl radical attack on dopamine