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RojasAJiangJGaneshTYangMSLelutiuNGueorguievaPet al

It is also important in drug metabolism, as most phase I enzymes including cytochrome P450 oxidases and some phase II enzymes localize to the ER 54

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We believe that requiring an FDA acceptance or filing letter would provide the clearest and most effective means of documenting that the applicant has submitted a complete request to FDA and are therefore proposing to require this approach to documentation