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Melatonin promoted AMPK phosphorylation and accelerated the translocation of PINK1 (PTEN-induced kinase 1) and Parkin to the mitochondria, thereby activating mitophagy [335]

We further confirmed their clearance capability by intravenously injecting the nanoclusters into nude mice and analyzing collected urine by inductively coupled plasma-mass spectrometry (ICP-MS), which revealed that 1020% of nanoclusters were rapidly eliminated through the renal clearance pathway within 2 days (Supporting Information Table S1)

In a light-induced AMD model, this formulation has shown promising results by regenerating photoreceptors and inhibiting harmful microglial activity

Molecular mechanisms and clinical implications of reversible protein S-glutathionylation

Chelation therapy is used in cases of increased toxic load, vascular disease or neurodegeneration

Vitamin E has been shown to inhibit cell ferroptosis in vitro and in GPX4/ gene knockout mice (Seiler et al., 2008