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Role of apamin-sensitive calcium-activated small-conductance potassium currents on the mechanisms of ventricular fibrillation in pacing-induced failing rabbit hearts

WC: Conceptualization, Formal analysis, Project administration, Writing original draft, Writing review & editing

Science 327 , 866868 (2010)

Further study is needed to determine the underlying reason for these differences

While the FDA advisory committee does not issue final approvals, their recommendations heavily influence the agency's decision-making process

Both are dominated by gastrointestinal adverse events nausea, vomiting, diarrhea, constipation, and abdominal pain that are mostly mild to moderate and concentrate during dose escalation