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Hazen explains that it all goes back to the Great Depression, when food shortages led people to experience health issues related to nutritional deficiencies including pellagra, aka niacin deficiency

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Of the two arms, one is designed to provide tumor specificity, while the other has the role of triggering the signaling potential

The initial two doses were given three weeks apart, and the third dose was given at least two months after their second dose

This means a lower and less predictable amount of the active compound might reach systemic circulation, potentially requiring higher doses and introducing variability into research findings

Third, major differences existed between the respective trial protocols