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Furthermore, it exhibits anti-oxidative and anti-inflammatory effects by suppressing nuclear factor-kappa B (NF-B) activation, reducing inflammatory cytokines, and increasing the anti-inflammatory cytokine interleukin-10

Acylcarnitine also plays a role in the pathological development of nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD) by affecting the DNA methylation pattern of macrophages and directing macrophage function in a proinflammatory direction [45]

A study in germ-free mice versus mice colonized with gut microbiota showed that the gut microbiota influences the hosts development of hypertensive organ damage, with TMAO and other microbial metabolites such as short-chain fatty acids (SCFAs) contributing to the phenotype (Avery et al., 2023)