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There is a need for more information on the entire sea buckthorns activity on ovarian functions (including dysfunctions and malignant transformation) both in vitro and in vivo

Its core pathological feature is excessive accumulation of adipose tissue, accompanied by abnormal proliferation, differentiation, and metabolic dysfunction of adipocytes, which in turn induce a series of complications including insulin resistance, nonalcoholic fatty liver disease, and cardiovascular diseases

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This may be due to the formation of DNA strand break and induction of apoptotic cell death signaling pathways in response to plasma treatment

SS-31 has a well-characterized preclinical safety profile and has been evaluated in multiple human clinical trials as elamipretide

2016;6(2): e194