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193,194 In considering L-carnitine administration, the Work Group confined evaluation of efficacy outcomes to RCTs in which the effect of IV L-carnitine on Hb level and ESA dosing had been reported in patients with CKD

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For example, Melatonin treatment significantly ameliorates the dysregulation of hepatic clock gene oscillations induced by high-fat high-fructose diet and jet lag in mice, restoring the rhythmic expression of Bmal1 and Clock while partially correcting oscillations in the Nrf2-HO-1 pathway

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