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Furthermore, p53 inhibits the expression of TIGAR (TP53-inducible glucolysis and apoptosis regulator), a regulator of glucose breakdown

To investigate the ability to generate a therapeutic effect, the multicellular tumor spheroids were treated with Ru(II)-OH, NP2, or NP4 (10 M Ru) in a 1% or 21% O 2 atmosphere and afterward incubated with a cell live or death stain

These mechanisms are thought to mitigate T-cell loss and senescence, thereby supporting more robust immune reconstitution once viral suppression is achieved

[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Chen C., Qu L., Li B., Xing L., Jia G., Wang T., Gao Y., Zhang P., Li M., Chen W., et al

doi:10.1016/j.ypmed.2016.01.022 Neglia, Danilo et al