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This variability may stem from the complex feedback networks involving ROS-mediated redox and phosphorylation modifications (Su et al., 2019

Int J Cardiol 2013;168(3):2310-4

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Among the various ROS, H 2 O 2 triggers the redox mechanism by targeting the receptor including protein tyrosine kinases, tyrosine phosphatases, and transcription factors via secondary messenger in intercellular signaling