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Large quantities of intracellular ROS hyperproduction are believed to participate in a diverse scope of either nonmalignant or malignant diseases that affect the nervous, cardiovascular, and respiratory tract disorders, including chronic obstructive pulmonary disease, GIT (e.g., inflammatory bowel disease and irritable bowel syndrome), urogenital, reproductive, and metabolic systems [20, 24], besides mental and immune system disorders [25]

In addition, NPTAs can also improve the sensitivity of MRI for biomarker detection and imaging of AD lesions

PMID 16234878

Accentuation of Signal Amplification this may occur with an increase in receptor phosphorylation or increased enzymatic activity

The programme is funded by NWO, the national research council of the Netherlands (Project No

Beyond alcohol and cocaine, the role of GlyT1 inhibition has been investigated in relation to nicotine-seeking behavior