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Disclosures: Michael Thornton: ENDRA Life Sciences Inc: Employee, Jang Hwan Cho: Endra Life Sciences, Inc.: Employee, Idan Steinberg: Nothing to Disclose, Jing Gao: Nothing to Disclose, Colby Adamson: Nothing to Disclose 838 DIFFERENTIAL IMPACTS OF GLP1R GENE VARIANTS ON DISEASE RISK AND TREATMENT EFFICACY IN AFRICAN AMERICANS Eleonora Scorletti 1 Helen Huang 1 David Zhang 1 Marijana Vujkovic 1 Joseph Park 1 Florian Kahles 2 Giorgio Sirugo 1 Michael Phillips 1 Kai Markus Schneider 2 Garret FitzGerald 1 Daniel Rader 1 Carolin Schneider 2 , 1 University of Pennsylvania, 2 University of Aachen Background: Previous studies in European cohorts have established associations between single nucleotide polymorphisms (SNPs) in the glucagon-like peptide 1 receptor gene (GLP1R) and both obesity and type 2 diabetes (T2D), conditions characterized by a fundamental insulin resistance

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The only limiting factors are typically adverse effects that increase with higher doses or the impracticality (physically or financially) of taking excessive amounts of these treatments