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It is also meant to guard against attributions of causality to biologically implausible statistical associations that might result from studies that have not adequately accounted for important variables

CD38 ligation plays a direct role in the induction of IL-1beta, IL-6, and IL-10 secretion in resting human monocytes

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5 Although these attempts have significant impacts on treating ageing and inflammation-associated diseases, the spatiotemporal regulation of pro-inflammatory cytokine release and its landscape have not been completely understood