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The most common mutation is a deletion that encompasses the first 10 exons of the gene along with portions of the CARKL gene upstream of CTNS

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A frequently used statistical technique to obtain this estimate with a corresponding 95% confidence interval is the MMRM

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Furthermore, the integration of genomic and transcriptomic profiling to develop refined IFN-related gene signatures holds significant potential for pretreatment patient stratification, enabling the identification of individuals who are likely to benefit from enhanced IFN signaling, as well as those whose tumor microenvironments may already be characterized by chronic IFN exposure and associated immunosuppressive effects