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For quantification of [ 15 N 13 ]-CNCbl, the influence of trace CNCbl originating from the endogenous cobalamins in the soybean flour was negligible due to addition of high amounts of exogenous CNCbl as internal standard

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Blood samples were collected at 2wpD (tp0), 7wpD (tp1) and 13wpD (tp2), with the latter two being taken 4 and 10 weeks post anti-PD1 (wpP), respectively ( Figure 1 )

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