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This makes aspartame undesirable as a baking sweetener and prone to degradation in products hosting a high pH, as required for a long shelf life

From the nervous system: central nervous system overexcitation, anxiety, headache, loss of consciousness, sleep disturbances, confusion, coma

As for the initial oxidation step ( i.e., Reaction 2), the favored species are the thiolate (nucleophile) and the protonated RSOH (electrophile), and hence, a bell-shaped pH dependency is expected for this reaction too

A landmark study showed a single low-dose klotho injection enhanced memory in aged nonhuman primates (Nature Aging, 2023)

H.ElboroughC.BhargavaN.RebstockR.et al