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Biochim Biophys Acta Mol Basis Dis (2020) 1866(3):165574

Vitale G, Salvioli S, Franceschi C

Although length of treatment and experimental model differed per study, all observed a drop in ATP levels and a depletion of NAD following exposure to high-dose VitC, in line with the inhibition of energy metabolism and multifaceted metabolic rewiring described in numerous pre-clinical studies using alternative approaches