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1 Introduction Parkinsons disease (PD) is a progressive neurodegenerative condition defined by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc) that causes a variety of motor and non-motor symptoms ( 14 bacteria, play crucial role in sustaining host health and affecting physiological systems such as the central nervous system (CNS)

Some studies have demonstrated that aged oocytes exhibit significant metabolic dysregulation, which contributes to meiotic irregularities 14,15

Their broad substrate range, including drugs and xenobiotics, and their high expression levels at the BBB, contribute a major part to CNS pharmacoresistance [75]

But its not all about changes to the reproductive system

Methylation is carried out by the class of enzymes called methyltransferases

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