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[11] [12] Peroutka and Snyder identified two distinct serotonin receptors and named them the 5-HT 1 receptor and 5-HT 2 receptor in 1979

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[24] The C-terminal intra-endosomal domain harbours the Zn-binding motif known as HEXXH(X)18E, as well as the exopeptidase motif GAMEN