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Abbreviations AD: Alzheimers disease AMPK: AMP-activated protein kinase APOE: Apolipoprotein E APP/PS1E9: Amyloid precursor protein/presenilin 1 E9 ATP: Adenosine triphosphate A: Amyloid-beta BBB: Blood-brain barrier BCL-2: B-cell lymphoma 2 BCL-XL: B-cell lymphoma-extra large CAR-T: Chimeric antigen receptor T-cell CDK5: Cyclin-dependent kinase 5 CNS: Central nervous system DNA: Deoxyribonucleic acid DRI: D-Retro-Inverso FOXO4: Forkhead box O4 FOXO4-DRI: FOXO4-D-Retro-Inverso fMRI: Functional magnetic resonance imaging GSK3: Glycogen synthase kinase 3 beta IL-1: Interleukin-1 beta IL-6: Interleukin-6 IND: Investigational New Drug JNK: C-Jun N-terminal kinase MCI: Mild cognitive impairment MoCA: Montreal Cognitive Assessment MRI: Magnetic resonance imaging OPCs: Oligodendrocyte precursor cells PARP: Poly (ADP-ribose) polymerase ROS: Reactive oxygen species SASP: Senescence-associated secretory phenotype TNF-: Tumor necrosis factor- 3xTg-AD: Triple transgenic Alzheimers disease References Abou Zaki R, El-Osta A (2024) Metformin: decelerates biomarkers of aging clocks

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Here are some of the best foods with B12: Clams, 3 ounces: 84 mcg 100% fortified breakfast cereal (check the label), 1 serving: 6 Trout, 3 ounces: 5.4 Salmon, 3 ounces: 4.9 Canned tuna fish, 3 ounces: 2.5 Fortified soy milk, chocolate (check the label): 1.7 Beef, 3 ounces: 1.5 Nonfat plain Greek yogurt, 6 ounces: 1.3 Swiss cheese, 1 slice: 0.9 Ham, 3 ounces: 0.6 Egg, 1 large: 0.6 Roasted chicken breast, 3 ounces: 0.3 Should you take a multivitamin