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Some examples include: Amyotrophic lateral sclerosis (Lou Gehrig's disease) with weakness and muscle wasting Radiculopathy (spinal nerve irritation or compression from various causes) with pain Distortion or loss of sensation, and/or weakness Diseases of the peripheral nerves, such as diabetic neuropathy, with distorted and diminished sensation and weakness Several primarily dystonic muscle diseases QUESTION See Answer Can medications cause muscle cramps