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Although companies have developed newer methods to test drug safety, these are not globally accepted by the FDA or EMA as proof of safety

10.1074/jbc.272.41.25907 211 MichellB

doi: 10.1016/J.BBABIO.2004.03.008 51 KehrerJP

Glu tathione S-transferase isoforms mu1 and mu5 ( GSTM1 and GSTM5 ), which are vital for protecting cells from oxidative damage, have been found to be hypermethylated in AMD samples compared to age matched controls (Figure 4B