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This crosslinking mechanism enables the formation of stable hydrogels capable of encapsulating antimicrobial agents and absorbing wound exudates while maintaining a moist environment, which is crucial for preventing infection and promoting healing 21,23

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There is also evidence that peripheral inflammation driven by gut dysbiosis can reduce expression of key protein degradation systems in the brain (such as ubiquitinproteasome pathway and autophagy genes), thereby accelerating the accumulation of toxic proteins [101]

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After blocking, plates were washed four times and 30 l/well of 2 g/ml monomeric His-tagged gH/gL diluted in blocking buffer was added to the plate and incubated for 1 hr