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Additionally, the metabolism of arginine influences macrophage polarisation, with M1 macrophages producing toxic nitric oxide (NO) and M2 macrophages contributing to tissue repair and healing through the arginase pathway (60, 61)

iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss

Figure 1 summarizes the timeline for discovery, biomarker investigations, and toxicokinetic studies for selected mycotoxins

Each subgroup is then analyzed in relation to the other using the volume (Criteria 1 and 2), average cost (Criteria 3 and 4), and reduction in variance (Criteria 5)