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28 The blood-labyrinth barrier (BLB) limits salicylate penetration into the inner ear, 29 meaning that high systemic doses are required to reach therapeutic cochlear levels, which in turn increases the risk of toxicity to neural structures, such as spiral ganglion neurons (SGNs) and auditory nerves

Remember that serotonin is on a see-saw with kynurenine (kicked up by the immune system)

Advanced Phase II conjugation reactions are catalyzed by superfamilies of transferase enzymes that use activated cosubstrates to form covalent bonds with electrophilic or nucleophilic centers on substrates

Finally, the c-RELp52 or RELAp50 NF-kB complex is released to the nucleus to activate the transcription of their target genes, such as the inactive interleukin precursors pro-IL-1, pro-IL-18, and pro-caspase-1

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Erastin is identified as an inhibitor of GSH synthesis