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These are studying different therapeutic approaches aiming (a) to reduce intramitochondrial oxidative stress (idebenone, coenzymeQ, vitamin E, iron chelators), (b) to enhance frataxin endogenous expression (erythropoietin, pioglitazone), or (c) to increase FRDA gene expression (HDAC inhibitors, interferon )

Cys-C deficiency can disrupt the dynamic balance between histone enzymes and their inhibitors, leading to the development of CVD such as AS [49]

doi: 10.1016/j.cell.2014.11.037 25 WhiteMJMcArthurKMetcalfDLaneRMCambierJCHeroldMJet al

Consomme 15ml soit une cuillre soupe deux fois par jour