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Endocr Rev 28(1):84116 Gu W, Winters KA, Motani AS, Komorowski R, Zhang Y, Liu Q et al (2010) Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor

The 4-week minimum at each phase exists because some side effects have delayed onset

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Using a dataset of 309 drugs, Varma studied the interrelation of physicochemical properties and the individual parameters of oral absorption to define the physicochemical space for optimum human oral bioavailability (Varma et al

no human validation Approach Published mouse regimen Pattern 5 mg/kg IP, ~3x/week Duration Several weeks Notes Animal only

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