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(181) conducted a study involving 15 postmenopausal women with moderate OSAHS, administering estrogen (either oral CEE at 0.625 mg/d, estradiol valerate at 1 mg/d, or transdermal estradiol at 8 mg/week) in conjunction with combined progesterone (MPA at 2.510 mg/d) over a period of 50 days, and found no significant reduction in sleep-disordered breathing events

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TEM, EE, PDI, Zeta potential and Visual Observations The characterization of the prepared CF-CA-L is essential for understanding their penetration capabilities, taking into account factors such as Transmission Electron Microscopy (TEM) data, Polydispersity Index (PDI), visual observations, and the encapsulated drug content