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These changes include foot care practices such as daily inspections for blisters, cuts, or calluses, regular exercise to reduce pain and improve muscle strength, quitting smoking to maximize blood flow, adopting a nutritious diet, decreasing alcohol consumption, managing blood glucose levels (especially for people with diabetes), ensuring a clutter-free environment to prevent falls, and reviewing current medications with a healthcare provider to mitigate potential adverse effects

In most cases, the evaluation turns up a manageable or benign explanation

Initially, this will be done by a medical professional

Most are mild, manageable, and improve as the body adjusts

Because sufficient amounts of IF are needed to bind to B12, and adequate stomach acid is required to activate IF, a deficiency of either can lead to a B12 deficiency and devastating health consequences

Patients with pernicious anemia have about three times the incidence of carcinoma of the stomach as the general population, so appropriate tests for this condition should be carried out when indicated