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These ketone bodies (KB), including acetoacetic acid (acetoacetate), acetone and beta-hydroxybutyric acid (HB), can be utilized by the brain, heart and skeletal muscle through the citric acid cycle (Krebs cycle) and act as an energy source when glucose is not readily available (see Figure 1) (57)

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Immobility, which was defined as the period the animal hung passively without limb movement, was scored[40]

In addition to their loss of function, certain mutants actively promote cancer cell survival, drive tumor progression, and enhance adaptability under stress