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2012 Dec;50(10):875-85

Ross AC, Caballero B, Cousins RJ, Tucker KL

IGF-1 is a hormone produced primarily in the liver in response to growth hormone (GH) secretion from the pituitary gland

By attenuating NNMT activity, 5Amino1MQ has been observed in preclinical settings to elevate NAD+ availability, enhance metabolic flux, and upregulate downstream signaling programs associated with cellular stress responses and energy expenditure (e.g., SIRT1)