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The Cochrane database of systematic reviews

Boost therapy of hepatocellular carcinoma by amplifying vicious cycle between mitochondrial oxidative stress and endoplasmic reticulum stress via biodegradable ultrasmall nanoparticles and old drug

But even without that level of customization, understanding the core dosing principles will put you ahead of most researchers fumbling through contradictory information online

That said, if any adverse effect is suspected to be dose-related, the dose can be reduced

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Anal Chem 87(20):1036210367 Kim H, Lee B-I, Byeon S-H (2015) The inner filter effect of Cr (VI) on Tb-doped layered rare earth hydroxychlorides: new fluorescent adsorbents for the simple detection of Cr (VI)