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After oral administration of sinigrin at a dose of 15 or 30 mol/kg body weight/day for 21 days in diabetic groups, bodyweight gain increased significantly compared with those of the diabetic control group

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Results Rationale for structure-based BNIP3 antagonist peptide design The design of molecules with selective affinity for desired targets associated with the mitochondrial pathway in both apoptotic and necrotic cell death represents a significant challenge in de novo drug design

10.1053/j.gastro.2012.10.003 Gastroenterology 19 BotschuijverS.RoeselersG.LevinE.JonkersD