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In both THP-1-derived macrophages and primary human bone marrow-derived macrophages, both Osimertinib and CP-24 significantly upregulated the transcription of M1 marker genes, including CD68, CD88, CD80, ITGAX, and CXCL16, while exerting minimal effects on the transcription level of M2 marker genes such as TGFB1 (Fig

the C-terminal protein cleavage comprises inducing a thio-induced C-terminal cleavage

It exerts anti-inflammatory, antioxidant, and anti-apoptotic effects, which contribute to the restoration of ovarian hormonal function

Decades of peer-reviewed research, a clear mechanism, a strong topical safety profile

doi: 10.3390/biomedicines11102791 244 ElbandrawyAMYousefAMMorganENEwaisNFEidMMElkholiSMet al

doi:10.1038/s41422-023-00844-w 54