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These results reinforce the idea that DS might be a metabolic disease due to the presence of biochemical alterations of fundamental pathways like the folate cycle, Hcy-Met cycle and Hcy trans-sulfuration 14

pKa of All 20 Amino Acids: Zwitterions and Amino Acids: A zwitterion, also known as a dipolar ion, is a molecule or ion that has both a positive and a negative charge within its structure, resulting in overall electrical neutrality

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