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Extracellular signals are mainly mediated by Wnt proteins, including Wnt3a, Wnt1, and Wnt5a

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Proceedings of the National Academy of Sciences 104 (22): 94109415

Oral administration faces substantial hurdlesacidic gastric milieu, digestive enzymes, rapid mucus clearance, and heterogeneous lesion distributionleading to suboptimal on-target exposure