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The subsequent buildup of lipofuscin, characteristic of lysosomal aggregates, is associated with metabolic disruptions and impaired autophagic function, establishing it as a key biomarker for cellular aging 29

Liver glutathione declines 35-50% in aged animals [7] , while brain glutathione drops by at least 50% over adult aging [8]

Not only does glutathione directly neutralize free radicals, but it also has the ability to regenerate other antioxidants, such as vitamins C and E, back to their active forms

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Although this receptor appears to play an important role as anti-inflammatory modulator, it appears unlikely to be primarily involved in the control of lung fibrogenesis [137]

The primary material classes, their target pollutants, and core mechanisms are conceptualised in Fig